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Nphs2-cre

Web21 feb. 2024 · Tg (NPHS2-cre)295Lbh. Mutation details : The human NPHS2 promoter, including the entire 5' untranslated region, was used to drive cre recombinase expression … Web008205 B6.Cg-Tg(NPHS2-cre)295Lbh/J These transgenic mice (commonly referred to as podocin-Cre mice) have expression of Cre recombinase directed to podocytes within kidney glomeruli by the human podocin ( NPHS2 ) promoter/enhancer region and may be useful in generating Cre-lox conditional knockouts for studying the role of podocyte nephrobiology …

Podocyte-specific deletion of tubular sclerosis complex 2 ... - PLOS

WebTools. Data Hub. Learn more about Addgene materials from user-contributed reports describing AAV and antibody experiments. Sequence Analyzer. Basic analysis for a user-entered sequence; includes restriction sites and map WebNPHS2-cre. 2024-11-19. B6.Cg-Tg(NPHS2-cre)295Lbh. 品系编号：GAP1021. 品系简称：NPHS2-cre. 品系特点：. NPHS2-Cre 小鼠可存活且可生育，Cre 重组酶的表达通过人 … heat exchanger pm https://vrforlimbcare.com

2012CB517600-G常见肾小球疾病发病机制及其早期诊断

WebGenetic mutations that affect glomerular podocyte function, such as NPHS1, NPHS2, ... Using Pax8-Cre/GR f l/f l mice, Kuppe et al. generated kidney epithelial cells-specific Nr3c1 (GR) knockout mice . These animals show no apparent abnormality in kidney development, indicating that renal epithelial GR is dispensable for kidney development. Web23 aug. 2024 · 肾脏病防治转化医学研究中心成立于2024年，研究中心由三个实验室组成：干细胞与肾脏再生实验室、紧密连接功能与疾病实验室、泌尿系肿瘤实验室。. 实验室以“开放、流动、联合、竞争”八字方针为指导，坚持以基础研究为主，将本实验室的多学科特色与 ... WebDiscoidin domain receptor 1 activation links extracellular matrix to podocyte lipotoxicity in Alport syndrome move pass or move past

Podocyte-specific expression of tamoxifen-inducible Cre …

Category:Podocyte-specific expression of cre recombinase in transgenic mice

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Nphs2-cre

Notch1 and Notch2 in Podocytes Play Differential Roles During …

Webd, Relative mRNA amount of Fn1, Col1a1 and Col3a1 in control and Ksp cre /Dab2 flox/+ mice with or without FA injection. ... Tory K, et al. Mutation-dependent recessive inheritance of NPHS2-associated steroid-resistant nephrotic syndrome. Nat Genet 46, 299–304 (2014). Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆

Nphs2-cre

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http://weizhenbio.cn/special.php?cid=47 Web19 nov. 2002 · Twenty- four transgenic founders were generated in which Cre recombinase was placed under the regulation of a 2.5-kb fragment of the human NPHS2 promoter. Previously, this fragment was shown to drive beta-galactosidase (β-gal) expression exclusively in podocytes of transgenic mice.

WebThe NPHS2 gene provides instructions for making a protein called podocin. Podocin is primarily found in the kidneys, which are organs that filter waste products from the blood … Web9 sep. 2024 · The NPHS2-Cre transgene comprises the Cre coding sequence under the control of 2.5 kb of the human NPHS2 promoter. The NPHS2 gene encodes Podocin, which is specifically expressed in podocytes. In their paper, Balkawade et al. observed a thickening of the glomerular basement membrane (GBM) in 24-week-old NPHS2-Cre mice, which …

WebNphs2.Cre + ;Coq6 flox/flox mutant mice show (A) reduced podocin staining (arrows) appearing only on a few capillary loops (arrow head), whereas (B) nephrin expression is … WebNPHS2 pathogenic variants are the most common podocyte gene defects. Yet, pathogenic variants are found only in a minority of SRNS patients. No homozygotes or compound heterozygotes were observed in 377 biopsy confirmed late-onset FSGS [52].In three large worldwide analyses, NPHS2 pathogenic variants were found in roughly 10% of the …

http://www.informatics.jax.org/allele/MGI:4442436

Web12 nov. 2024 · cre工具鼠详细介绍 / 开普饭. cre小鼠是什么？. cre工具鼠详细介绍. 研究人员使用基因编辑的小鼠模型来研究基因表达，研究遗传疾病，进行临床前药物药效测试等。. 在许多研究中，小鼠模型在其整个发育和生命过程中均表达基因突变。. 然而，在某些研究中 ... move pc game pass gamesWebThe Jackson Laboratory nphs2 also known as podocin cre mice. Nphs2 Also Known As Podocin Cre Mice, supplied by The Jackson Laboratory, used in various techniques. … heat exchanger pipeWebCre 蛋白是一种重组酶，是causes recombination的缩写，于1981 年从 P1 噬菌体中被发现，属于 λInt 酶超基因家族。 Cre 重组酶基因编码区序列全长1029bp，编码 38kDa 蛋白 … heat exchanger plate dimensionsWebDownload scientific diagram Conditional Nphs2 knockout mice have various phenotypes. (A) Kaplan-Meier survival curve of control and Nphs2 lox2/ mice upon Cre activation by … heat exchanger pinch analysismove patient from bed to chairWeb13 apr. 2024 · Due to the podocyte-specific action of the Nphs2 (podocin) promoter-triggered Cre-recombinase, the stop cassette was removed and mWT- or mI93M-UCH-L1 overexpression on glomerular podocytes was ... heat exchanger poolWebCre-LoxP系统在小鼠中的应用已经相当广泛了，很多基因都有对应的LoxP小鼠存在，同时特异性启动子的Cre小鼠资源也相当丰富。 但是在大鼠中，由于基因编辑技术发展的落后，目前无论是LoxP大鼠还是连接了组织特异性启动子的Cre大鼠，它们的种类都要远低于小鼠。 movepenaltyfordelayfire